Main Article Content
The aim of this review article is to outline the role of the plant Cannabis sativa in treating human ailments. Giant pharmaceutical
companies are marketing phytochemicals extracted from Cannabis plant and its derivatives to treat epilepsy and multiple sclerosis.
The present review emphasizes cannabinoids – its derivatives and synthetic analogs – as an active pharmaceutical Ingredient to treat
ailments related to autoimmune human body responses. The endocannabinoid system CB1 and CB2 respond differently to various
phytochemicals such as cannabidiol, tetrahydrocannabinol and terpenes. They also interact with the endogenous ligands synthesized by
the human body. The role of nanotechnology in the design of a drug delivery system is discussed in this review. The advantages with the
use of Quantum dots are briefly outlined. Cannabis-based phytochemicals are known for psychotic and non-psychotic effects. We have
underlined the immense potential of this plant in treating diseases. Cannabidiol (CBD) as one of the main non-psychotic phytochemicals,
has established itself as an active pharmaceutical agent in some approved medicines worldwide. Cannabis-based phytochemicals can be
used as targeted drug delivery vehicles. Future direction in this field could be a synthesis of derivatives of cannabidiol and its targeted
drug delivery to the cannabinoid receptors. In the oral route, the terpenes give the wholesome experience of consuming Cannabis.
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Al-naqeeb, G., Bajilan S., Baqer M, 2017. Effect of silver nanoparticles on the ovary of PCOS-induced female mice: A histopathological study. Global Journal of Bio Science and Biotechnology.6(4):623-30. doi: 10.20959/WJPR201711-9483
Bajwa N, Mehra NK, Jain K, Jain NK, 2016. Pharmaceutical and biomedical applications of quantum dots. Artificial cells, nanomedicine, and biotechnology. 44(3):758-68. doi: 10.3109/21691401.2015.1052468
Bouchard JF, Casanova C, Cécyre B, Redmond WJ, 2015. Expression and Function of the Endocannabinoid System in the Retina and the Visual Brain. Neural plasticity. Volume 2016: 15-19. doi: 10.1155/2016/9247057.
Brents LK. 2016 Focus: sex and gender health: Marijuana, the Endocannabinoid System, and the female reproductive system. The Yale journal of biology and medicine 89(2):175.
Burstein S. 2015 Cannabidiol (CBD) and its analogues: a review of their effects on inflammation. Bio-organic & medicinal chemistry. 23(7):1377-85. doi: 10.1016/J.BMC.2015.01.059.
Chen M, Yin H, Bai P, Miao P, Deng X, Xu Y, Hu J, Yin J, 2016. ABC transporters affect the elimination and toxicity of CdTe quantum dots in liver and kidney cells. Toxicology and Applied Pharmacology. 303:11-20.
Conte R, Marturano V, Peluso G, 2017. Recent advances in nanoparticle-mediated delivery of anti-inflammatory phytocompounds. International journal of molecular sciences. 18(4):709
Devane WA, Hanus L, Breuer A, Pertwee RG, Stevenson LA, Griffin G, Gibson D, Mandelbaum A, Etinger A, Mechoulam R, 1992. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science. 258(5090):1946-9.
Drbohlavova J, Adam V, Kizek R, Hubalek J., 2009. Quantum dots—characterization, preparation and usage in biological systems. International journal of molecular sciences. 10(2):656-73.
Farmer S, Slavin MN, Loflin MJ, Luba R, Earleywine M., 2019 Aversiveness and Meaningfulness of Uncomfortable Experiences with Edible Cannabis. Journal of psychoactive drugs. 51(5):413-20.
Fezza F., Bari M., Florio R., Talamonti E., Feole M., Maccarrone M., 2014. Endocannabinoids, related compounds, and their metabolic routes. Molecules 19: 17078–17106.
Gaoni Y. and Mechoulam R. 1964. Isolation, structure, and partial synthesis of an active constituent of hashish. J. Amer. Chem. Soc. 86:1646–1647.
Hamidi M, Azadi A, Rafie P, Ashrafi H, 2013. A pharmacokinetic overview of nanotechnology-based drug delivery systems: an ADME-oriented approach. Critical Reviews™ in Therapeutic Drug Carrier Systems.30(5):435-67.
Hardman R., 2006. A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors. Environmental health perspectives.114(2):165-72.
He K, Liang X, Wei T, Liu N, Wang Y, Zou L, Lu J, Yao Y, Kong L, Zhang T, Xue Y., 2019. DNA damage in BV‐2 cells: An important supplement to the neurotoxicity of CdTe quantum dots. Journal of Applied Toxicology. 39(3):525-39.
Hoshino A, Hanada S, Yamamoto K., 2011 Toxicity of nanocrystal quantum dots: the relevance of surface modifications. Archives of toxicology.85(7):707.
Hou CC. and Zhu JQ., 2017. Nanoparticles and female reproductive system: how do nanoparticles affect oogenesis and embryonic development. Oncotarget. 8:109799-109817
Iversen L., 2008. Published by Oxford University Press: Oxford, UK. 2008. 273 pp ISBN-13: 978-0-19-532824-0.
Jović D, Jaćević V, Kuča K, Borišev I, Mrdjanovic J, Petrovic D, Seke M, Djordjevic A., 2020. The Puzzling Potential of Carbon Nanomaterials: General Properties, Application, and Toxicity. Nanomaterials.10(8):1508.
Kang YF, Li YH, Fang YW, Xu Y, Wei XM, Yin XB., 2015.Carbon quantum dots for zebrafish fluorescence imaging. Scientific reports.5(1):1-2
Kara HE. and Ertaş N., 2017. Quantum Dots for Pharmaceutical and Biomedical Analysis. Spectroscopic Analyses - Developments and Applications. 6:143-164. DOI: 10.5772/intechopen.70034
Kaur K, Singh A, Sidhu YS, 2019. Advances in combination of quantum dots and nanotechnology-based carrier systems against cancer-A critical review. International Journal of Bio-Pharma Research. 8(12):2814-25.
Klostranec J.M. and Chan W.C., 2006. Quantum dots in biological and biomedical research: recent progress and present challenges. Advanced Materials.18(15):1953-64.
Lewis MM., Yang Y., Wasilewski E, Clarke HA, Kotra LP., 2017. Chemical profiling of medical cannabis extracts. ACS omega. 2(9):6091-103.
Li YF, Zhao J, Gao Y., 2016. Nanometallomics: New Approach on Analyzing Biological Effects of Metal-Related Nanomaterials1. Toxicology of Nanomaterials.6:220-32.
Lombardo F, Desai PV, Arimoto R, 2017. In Silico Absorption, Distribution, Metabolism, Excretion, and Pharmacokinetics (ADME-PK): Utility and Best Practices. An Industry Perspective from the International Consortium for Innovation through Quality in Pharmaceutical Development: Miniperspective. Journal of Medicinal Chemistry.60(22):9097-113.
Lu H, Schöps O, Woggon U, Niemeyer CM., 2018. Self-assembled donor comprising quantum dots and fluorescent proteins for long-range fluorescence resonance energy transfer. Journal of the American Chemical Society.130(14):4815-27.
Maremmani I, Lazzeri A, Pacini M, 2014. Diagnostic and symptomatological features in chronic psychotic patients according to cannabis use status. Journal of psychoactive drugs. 36(2):235-41.
Matsuda LA., Tom I. Bonner, Stephen J. Lolait, 1993. Localization of cannabinoid receptor mRNA in rat brain, The Journal of Comparative Neurology, 327(4):535-550 https://doi.org/10.1002/cne.903270406
Mechoulam R., Ben-Shabat S., Hanus L., Ligumsky M., Kaminski NE., Schatz AR., Gopher A, Almog S., Martin BR., Compton DR., 1995. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochemical Pharmacology. 50(1):83-90.
Mechoulam R., Hanuš LO., Pertwee R., Howlett AC., 2014. Early phytocannabinoid chemistry to endocannabinoids and beyond. Nature Reviews Neuroscience. 15(11):757-64.
Mechoulam R, Peters M, Murillo‐Rodriguez E, 2007. Cannabidiol–recent advances. Chemistry & biodiversity. 4(8):1678-92.
Missaoui WN, Arnold RD, Cummings BS, 2018. Toxicological status of nanoparticles: what we know and what we don't know. Chemico-biological interactions. 295:1-2.
Nelson, P. L. (1993). A critical review of the research literature concerning some biological and psychological effects of cannabis. In Advisory Committee on Illicit Drugs (Eds.), Cannabis and the law in Queensland: A discussion paper (pp. 113-152).
NCBI., 2020. PubChem Compound Database; CID=644019 August 08 2020; Available from: https://pubchem.ncbi.nlm.nih.gov/compound/644019
Ogborne AC., Smart RG., Weber T., Birchmore-Timney C., 2000. Who is using cannabis as a medicine and why: an exploratory study. Journal of psychoactive drugs. 32(4):435-43.
O’Llenecia SW., Holloway AC., Raha S., 2019. The role of the endocannabinoid system in female reproductive tissues. Journal of ovarian research. 12(1):1-10. doi: 10.1186/S13048-018-0478-9/FIGURES/2
Pawar RS., Upadhaya PG, Patravale VB., 2018. Quantum Dots: Novel Realm in Biomedical and Pharmaceutical Industry. In Handbook of Nanomaterials for Industrial Applications. 621-637. Elsevier. doi: 10.1016/B978-0-12-813351-4.00035-3.
Reshma VG. and Mohanan PV., 2019. Quantum dots: Applications and safety consequences. Journal of Luminescence. 2019 Jan 1; 205:287-98. doi: 10.1016/J.JLUMIN.2018.09.015.
Riviere JE., 2009. Pharmacokinetics of nanomaterials: an overview of carbon nanotubes, fullerenes and quantum dots. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. (1):26-34. doi: 10.1002/WNAN.24.
Rizvi SB, Ghaderi S, Keshtgar M., 2010. Semiconductor quantum dots as fluorescent probes for in vitro and in vivo bio-molecular and cellular imaging. Nano reviews. 2010. 1(1):5161.
Rosenthal SJ., Chang JC., Kovtun O., McBride JR., 2011. Tomlinson ID., 2011. Biocompatible quantum dots for biological applications. Chemistry & Biology. 18(1):10-24. doi: 10.1016/J.CHEMBIOL.2010.11.013.
Skorupska S, and Grabowska-Jadach I., 2019. Cytotoxicity studies of quantum dots with the electroporation method. Bioelectrochemistry. 126:86-91. doi:10.1016/J.BIOELECHEM.2018.11.011.
Sugiura T, Kondo S, Sukagawa A, Nakane S, Shinoda A, Itoh K, Yamashita A, Waku K., 1995. 2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain. Biochemical and Biophysical Research Communications. 215(1):89-97.
Trivedi M, Johri P, Singh A, Singh R, 2020. Latest Tools in Fight Against Cancer: Nanomedicines. NanoBioMedicine 2020 (pp. 139-164). Springer, Singapore. https://doi.org/10.1007/978-981-32-9898-9_6
Ueda N., Tsuboi K., Uyama T., 2013. Metabolism of endocannabinoids and related N-acylethanolamines: canonical and alternative pathways. The FEBS Journal. 280:1874–1894.
Wang Y., Hu R., Lin G., Roy I., Yong KT., 2013. Functionalized quantum dots for biosensing and bioimaging and concerns on toxicity. ACS applied materials & interfaces. 5(8):2786-99.
Wu T, Tang M., 2018. Review of the effects of manufactured nanoparticles on mammalian target organs. Journal of Applied Toxicology. 38(1):25-40.
World Health Organization. Cannabidiol (CBD) critical review report., 2018. In Expert Committee on Drug Dependence Fortieth Meeting, Geneva 2018 Jun 4, 19-21.
Xu J, Wang L, Mu Y, Zhang Y, Wang M, Wang Q, Wang K, Guan S, Li J, Wang L., 2018. Carbon Quantum Dots as Fluorescent Probes for Imaging and Detecting Free Radicals in C. elegans. Journal of Nanoscience and Nanotechnology. 18(2):763-71. doi: 10.1166/JNN.2018.15190.