Antimicrobial Activity of Plant-derived Pongamol and its Derivatives

Abstract

Many plant-derived phytomolecules have antimicrobial properties, useful against drug-resistant pathogens. In this study, some new derivatives of pongamol were synthesized by treating pongamol with different reagents to produce pyrazole, oxazole, pyrimidine, and diazepine systems and evaluating their antibacterial activity against different strains of bacteria. Pongamol, a phytochemical from Tephrosia purpurea seeds and Pongamia pinnata oil, exhibits antibacterial properties and can serve as a model for synthesizing novel antimicrobial compounds with the potential for fewer side effects. The synthesized compounds were screened for their in vitro antimicrobial potential against different strains of bacteria, Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli, using minimal inhibitory concentration (MIC) and zone of inhibition methods, with clarithromycin as the standard drug. Compound A5 showed greater activity than clarithromycin against E. coli, while A2 and A3 have better activity than standard drugs in the case of S. aureus in a zone of inhibition. (A1-A5) have greater activity than standard drugs. In MIC, all compounds (A1-A5) are more active than the clarithromycin in P. aeruginosa.